Combined metabolic, phenomic and genomic data to prioritize atrial fibrillation-related metabolites
نویسندگان
چکیده
منابع مشابه
Genomic medicine and atrial fibrillation.
Recent developments and improved understanding in genomics (the interactions and functions of genes) have profoundly changed the perspective of researchers and medical practitioners toward diseases that had previously been associated with environmental factors alone (1). It is now widely recognized that many common disorders, such as heart disease, cancer, infections, Parkinson’s disease, and A...
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Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice, and the lifetime risk of developing AF is 25%. Even in the absence of structural heart disease AF is extremely common and is associated with an increased risk of stroke, heart failure, and death. Risk factors for AF are age, sleep apnoea, valvular heart disease, hypertension, obesity, male gender, and type 2 diabe...
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The EcoCyc system consists of a knowledge base (KB) that describes the genes and intermediary metabolism of Escherichia coli, and a graphical user interface (GUI) for accessing that knowledge. This paper addresses two problems: How can we create a GUI that provides integrated access to metabolic and genomic data? We describe the design and implementation of visual presentations that closely mim...
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BACKGROUND Left atrial enlargement and persistent atrial fibrillation (AF) are well-known predictors for arrhythmia recurrence after AF catheter ablation (LRAF). In this study, by using pathway enrichment analysis of GWAS data, we tested the hypothesis that genetic pathways associated with these phenotypes are also associated with LRAF. METHODS Samples from 660 patients with paroxysmal (n = 3...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2019
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2019.7443